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Molecular Weight: 334.33
Description: a small-molecule inhibitor of DNMT( DNA methyltransferases)
RG108 inhibits DNA methylation in human cancer cell lines without toxicity in vitro. It causes demethylation and reactivation of tumor suppressor genes. It enhances the efficiency of induced pluripotent stem cell generation.
Chemical structure:
Molecular formula: C 19H14N2O4
CAS Number: 48208-26-0
Purity: ≥98% by HPLC
Storage: -20oC
Solubility: Soluble in DMSO to 100mM
References:
Brueckner et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 65 6305. PMID: 16024632.
Stresemann C et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.Cancer Res 66:2794-800 (2006). PMID: 16510601.
NMR Spectroscopy:
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