RG108

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Chemical Name: N-Phthalyl-L-tryptophan

Molecular Weight: 334.33

Description: a small-molecule inhibitor of DNMT( DNA methyltransferases)
RG108 inhibits DNA methylation in human cancer cell lines without toxicity in vitro. It causes demethylation and reactivation of tumor suppressor genes. It enhances the efficiency of induced pluripotent stem cell generation.

Chemical structure:

Molecular formula: C₁₉H₁₄N₂O₄

CAS Number: 48208-26-0

Purity: ≥98% by HPLC

Storage: -20^oC

Solubility: Soluble in DMSO to 100mM

References:
Brueckner et al (2005) Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of DNA methyltransferase. Cancer Res. 65 6305. PMID: 16024632.
Stresemann C et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.Cancer Res 66:2794-800 (2006). PMID: 16510601.

NMR Spectroscopy:

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