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LDN193189
Chemical Name: 4-[6-(4-Piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride

Molecular Weight: 406.48

Description: BMP pathway inhibiot, inhibits ALK2,ALK3,ALK6, it shows antiatherosclerotic effects in vivo by inhibiting the production of reactive oxygen species. It inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to study the role of osteogenesis in prostate tumor metastases in bone.
 
Chemical structure: 



Molecular formula: C 25H22N6

CAS Number: 1062368-24-4

Purity: ≥98% by HPLC

Storage: -20oC

Solubility: Soluble in DMSO
 
References:
Yu et al. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol 4: 33-41.
 
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.


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