Tubastatin A

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Chemical Name: 1-[3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

Molecular Weight: 244.3

Description: Tubastatin A is a potent and selective inhibitor of HDAC6 with an IC50 value of 15 nM. Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures.

Chemical structure:

Molecular formula: C₂₀H₂₁N₃O₂•HCl

CAS Number: 1310693-92-5

Purity: ≥99% by HPLC

Storage: -20^oC

Solubility: Soluble in DMSO

References:
Butler et al, Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc 2010, 132(31):10842-10846.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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