Microphthalmia-associated transcription factor (Mitf) is a member of the basic/helix-loop-helix/leucine zipper (b-HLH-ZIP) transcription factor subfamily. Mitf regulates the differentiation of melanocytes, optic cup-derived retinal pigment epithelium (RPE), and some types of bone marrow-derived cells. Mitf is crucial for normal retina and  RPE development. This lentivirus expresses one of the isoform of Mitf, human Mitf-D, under the control of the Tet promoter.

Virus: Inducible tet-on Mitf-D lentivirus
Titer (approx): 1 x 108 CFU/ml
Vector Information: Vector includes both 5’ and 3’ lentiviral LTR and all necessary elements for effective transduction; woodchuck hepatitis virus posttranscriptional regulatory element (WPRE)
Promoter for Target Gene: TRE
Target Gene / Reporter(s): Mitf-D
Selection Gene: Puromycin
Biosafety Level: BSL-2
Shipped: Dry ice
Storage: Store at -80°C

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