mMKOS stands for 4 mouse stem cell factors which are c-Myc-F2A-Klf4-T2A-Oct4-E2A-Sox2 ((BC006728 NM_010637 NM_013633 NM_011443). Ad-GFP-mMKOS use 2A “self-cleaving” peptides, which support efficient polycistronic expression from a single promoter to reduce the number of viruses necessary to reprogram somatic cells. Ad-GFP-mMKOS also has a separate expression cassette to express eGFP.
Product Category: human Adenovirus Type5 (dE1/E3).
Application: Mouse KOSM adenovirus can be used to generate induced pluripotent stem (iPS) cell from mouse and human adult fibroblasts.